National blogger RedState suggests Sen. Mitch McConnell might face a challenge to his leadership position from Senate Republicans:
After 2008, McConnell either wins or loses. If he loses, John Kyl will probably become Minority Leader, moving up from Whip. If McConnell wins, he might still face a coup if the GOP Senate conference feels the need to go in a new, more conservative direction after a disastrous 2008 election cycle. If the GOP does get slaughtered at the polls, it will likely be moderate Senators bearing the brunt of the voters anger, making the remaining GOP caucus more conservative and more willing to vote their own into leadership. So, Kyl might take the reins then too.
With Kyl as leader, Cornyn will run for Whip, with a reduced number of Republican Senators, but a more conservative group. Sessions will get to Policy, which is what he wants, and that leaves DeMint available to be the Party's message guy in Conference Chair. That'll leave open a slot as VP for Conference, which a good conservative could fill.
Imagine, post 2008, having the top Senate Republicans be, in order: Kyl, Cornyn, DeMint, Sessions, and an as yet to be determined conservative.
One note, just so I don't get accused of anything I don't mean -- I'm not hoping that the GOP gets wiped out in 2008. I hope, in fact, that it doesn't. But I can see the writing on the wall. And sometimes, it takes hitting rock bottom for addicts to want recovery -- especially when they're addicted to earmarks. Let's just pray to God that if we do get slaughtered that we don't fall under 41.